ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Nifedipine degradation by an electro-oxidation process using titanium-based RuO₂–IrO₂–TiO₂ mixed metal oxide electrode

Mohd Dzul Hakim Wirzal, Palanivel Sathishkumar, Lina Abdullah Alshahrani, Abdull Rahim Mohd Yusoff, Feng Long Gu, Munawar Saeed Qureshi, Muhammad Khalid, and Faiz Muhammad Khokhar

Chemical Engineering Department, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, Malaysia

E-mail: rahim@kimia.fs.utm.my

Received: 23 November 2019  Accepted: 4 June 2020

Abstract:

The interest in new emerging pollutants (NEPs) does not only focus on the main compounds but also the degradation or intermediate products. It is important to have an effective primary treatment for the removal/degradation of NEPs from hospital and clinical wastewater to protect the environment. In this study, nifedipine degradation was performed by an electro-oxidation method using titanium-based mixed metal oxide (MMO) electrode. The determination of nifedipine was carried out by differential pulse voltammetry at hanging mercury drop electrode using Britton–Robinson buffer (BRB). The nifedipine oxidation peak was observed at + 0.7 V at a scan rate of 20 mV s⁻¹ in BRB pH 8. Titanium-based electrodes with different metal oxide compositions were assessed as an anode material for nifedipine degradation as follows: TiO₂/Ti, IrO₂–TiO₂/Ti, RuO₂–TiO₂/Ti, and IrO₂–RuO₂–TiO₂/Ti. The electro-oxidation of nifedipine was monitored using cyclic voltammetric techniques, and the degradation intermediates were confirmed using LC–MS. Approximately 65–83% of nifedipine degradation was achieved using RuO₂–TiO₂/Ti and IrO₂–TiO₂/Ti electrodes. Interestingly, RuO₂–IrO₂–TiO₂ electrode showed complete (100%) electro-oxidation of nifedipine at 30 min. Two nifedipine degradation intermediates were identified, namely 5-methoxycarbonyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3-carboxylic acid (compound I) and 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarbaldehyde (compound II) during the electro-oxidation process using RuO₂–IrO₂–TiO₂ electrode. Finally, the degradation pathway of nifedipine by MMO electrode was proposed. This is the first report on the nifedipine degradation using MMO titanium electrode by the electro-oxidation process.

Keywords: Degradation; Electro-oxidation; Mixed metal oxide; Nifedipine; Titanium anode

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-020-01243-w

Chemical Papers 75 (2) 681–690 (2021)