ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Photodynamic efficiency of porphyrins encapsulated in polysilsesquioxanes

Renata Rychtáriková, Stanislav Šabata, Jiří Hetflejš, and Gabriela Kuncová

Department of Organic Synthesis and Analytical Chemistry, Institute of Chemical Process Fundamentals of the AS CR, CZ-165 02 Prague 6 — Suchdol, Czech Republic

E-mail: rychtarikova@icpf.cas.cz

Abstract: Mesoporous organosilica-porphyrin composites were obtained by entrapment of 5,10,15,20-tetraphenylporphyrin (TPP) and 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin (TMPyP) into three polysilsesquioxanes prepared by the sol-gel method from 1,2-bis(triethoxysilyl)ethane, 1,6-bis(triethoxysilyl)hexane, and 1,8-bis(triethoxysilyl)octane. The materials were characterised by their texture and optical properties (fluorescence and absorbance) and by light-induced antimicrobial activity against E. coli BL21(DE3) (pET16bDsRed) strain.

Keywords: porphyrin – immobilisation – specific surface area – absorbance – fluorescence – bacteria – photoinactivation

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-012-0153-3

Chemical Papers 66 (4) 269–277 (2012)