ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Catalytic activity of Schiff base monocrystal and its application for colorimetric detection of dopamine

Qinghua Weng, Shuyu Chen, Jinquan Yi, Siqi Huang, Jiaye Wang, Fei Wang, Xing Shang, Jie Kang, and Zhizhong Han

School of Pharmacy, Fujian Medical University, Fuzhou, People’s Republic of China

E-mail: zzhan@fjmu.edu.cn

Received: 21 May 2020  Accepted: 27 September 2020

Abstract:

In this work, we used 2-amino-4-methylphenol and terephthalaldehyde as reactants to synthesize a new type of Schiff base crystal (MAPTPA). It is yellow with an empirical formula of C₂₂H₂₀N₂O₂. The synthesized MAPTPA exhibits an intrinsic visible light-induced oxidase-like catalytic activity without the use of destructive H₂O₂. The results show that dissolved oxygen plays an important role in the catalytic reaction process and ¹O₂ is the crucial reactive species responsible for TMB oxidation. The results of Michaelis–Menten kinetics demonstrate that MAPTPA has high substrate affinity and catalytic efficiency. Based on the catalytic activity of MAPTPA, we developed a sensitive visual sensing strategy for dopamine (DA) detection. A high linear relationship is observed in the range of 0.01–100 μM with a detection limit (LOD) of 6.70 nM. Therefore, the as-prepared Schiff base monocrystal may be used as an oxidase mimic for life sciences in the future, such as biosensor, biosynthesis, photodynamic therapy, etc.

Keywords: Schiff base; Oxidase mimic; Catalytic activity; Colorimetric detection; Dopamine

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-020-01381-1

Chemical Papers 75 (3) 1259–1266 (2021)