ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

A garlic oil-based organo-hydrogel for use in pH-sensitive drug release

Duygu Alpaslan, Tulü Olak, Abdullah Turan, Tuba Ersen Dudu, and Nahit Aktas

Engineering Faculty, Department of Chemical Engineering, Campus, Van Yüzüncü Yil University, Van, Turkey

E-mail: alpaslanduygu@gmail.com

Received: 18 February 2021  Accepted: 25 June 2021

Abstract:

In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Ce and Cp release properties of the prepared organo-hydrogels were also determined. The highest Ce release rate was obtained to be 37.8% for p (AG-g-GO)³ at pH 8.0 after 7 days. However, the highest Cp release rate was found to be 95.4% for p (AG-g-GO)³ at pH 7.4 after 1 day.

Keywords: Organo-hydrogel; Agar; Garlic oil; Ceftriaxone; Carboplatin

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-01760-2

Chemical Papers 75 (11) 5759–5772 (2021)