ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis and characterization of hydroxyapatite and composite based on it with collagen/alginate

Alla Serhiienko, Tetiana Dontsova, Olena Yanushevska, Andrii Lapinskyi, and Grigory Krymets

Department of Technology of Inorganic Substances, Water Purification and General Chemical Technology, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Peremohy, Ukraine

E-mail: allasergienko706@gmail.com

Received: 2 April 2021  Accepted: 26 August 2021

Abstract:

The current work considers the synthesis of hydroxyapatite by heterogeneous and homogeneous (gradient-free) chemical precipitation from various precursors. The obtained hydroxyapatite samples were characterized by XRD, IR, and Raman spectroscopies. XRD and Raman spectroscopy showed that in all cases, only one crystalline phase of hydroxyapatite had been obtained. The results of IR spectroscopy had indicated contamination of hydroxyapatite samples, except for HAp sample, which was obtained by heterogeneous precipitation method using calcium saccharate. It had been shown that it bound to collagen chemically in synthesized composites. The creation of double and triple composites with HAp and sodium alginate led to the obtaining of composites with a content corresponding to natural bone tissue. It had been found that in the obtained balls of HAp/collagen/alginate composite, there were pores through which the transport of calcium ions and their accumulation in NaCl solution was observed. Overall, it had been considered that the use of the obtained balls based on triple HAp/collagen/alginate composite would be promising not only for the delivery of calcium ions to the destination but also for the delivery of other drugs.

Keywords: Hydroxyapatite; Heterogeneous precipitation method; Homogeneous precipitation method; HAp/collagen composite; HAp/collagen/alginate composite

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-01841-2

Chemical Papers 76 (1) 385–392 (2022)