ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Inhibitory effect of two coordination polymers combined with LL-37 against lung cancer

Xiao-Xia Li, Zhao Han, Yan-Kun Zhang, Hui-Gai Song, Na Liu, Gui-Yun Zhu, and Mei-Li Xu

Pathology Department, Hebei Chest Hospital, Shijiazhuang, China

E-mail: 15633037126@163.com

Received: 21 September 2021  Accepted: 17 November 2021

Abstract:

Through utilizing the mixed-ligand approach, two coordination polymers containing Co(II) (namely, {[Co(HDCPN)(4,4′-bpy)(CH₃CH₂OH)(H₂O)₂]·0.5CH₃CH₂OH}_n (1) and {[Co₃(DCPN)₂(4,4-bibp)₄(H₂O)₄]·2CH₃CH₂OH·5H₂O}_n (2)) have been generated with a hydrothermal condition by the reaction between H₃DCPN (6-(3,5-dicarboxylphenyl)nicotinic acid) and Co(NO₃)₂·6H₂O with various N-donor co-ligands. On the lung cancer treatment, their application values were investigated and the associated mechanism was tested in meantime. First of all, the Cell Counting Kit-8 kit was implemented and the compounds’ inhibitory effect against the lung cancer cells viability was determined. Moreover, the trans-well detection was also carried out and the lung cancer cells invasion and migration ability was measured after finishing the specific treatment. The vascular endothelial growth factor (VEGF) signaling pathway expression in the levels of protein and mRNA was examined through western blotting detection and real time reverse transcription-polymerase chain reaction (RT-PCR) assay, respectively.

Keywords: Coordination polymers; Lung cancer; VEGF; RT-PCR

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-01989-x

Chemical Papers 76 (4) 2167–2175 (2022)