ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Two new Ag(I)-based compounds: luminescence and enhancing acupuncture treatment activity on ovarian cancer

Meng-Jie Chen, Yao-Hua Chen, and Xue-Lian Hui

Department of Gynaecology, Xi’an Hospital of Traditional Chinese Medical, Xi’an, China

E-mail: huixl198@163.com

Received: 7 March 2022  Accepted: 19 April 2022

Abstract:

This contribution reported two fresh Ag(I)-based compounds, as known as [Ag₂(L1)(H₂O)]_n (1) and [Ag₂(L2)(NO₃)₂]_n (2) (H₂L1 = 1,4,8,9-tetraazatriphenylene-2,3-dicarboxylic acid, L2 = tris(pyridin-2-yl)-1,3,5-triazine), that were formed in hydrothermal environments and further structurally researched by the aid of powder X-ray diffraction, elemental analysis, X-ray single crystal diffraction and thermogravimetric analysis. Under appropriate excitation wavelength, the solid powders of 1 and 2 are luminescent. Their effect on the ovarian cancer combined with acupuncture was investigated and the related principle also was studied in the meantime. The Cell Counting Kit-8 (CCK-8) assay was firstly accomplished and the inhibitory effect of the fresh compounds on the cancer cells was appraised. Then, the activity of the vascular endothelial growth factor (VEGF) signaling route in the ovarian cancer cells was evaluated as well.

Keywords: Ag(I) compounds; Hydrothermal synthesis; 3D framework; Luminescence; Ovarian cancer

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02251-8

Chemical Papers 76 (9) 5411–5419 (2022)