ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Efficient synthesis of celecoxib and pyrazole derivatives on heterogeneous Ga-MCM-41-SO₃H catalyst under mild condition

Tran Quang-Hung, Tu T. Do, Viet Q. Hoang, Duc M. Tran, Ngo Quoc-Anh, Tuan-Anh L. Hoang, Reinhard Eckelt, Dang V. Do, Tuan T. Dang, and Xuan-Hoan Vu

Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

E-mail: dangdovan@hus.edu.vn

Received: 17 May 2022  Accepted: 23 August 2022

Abstract:

The application of Ga-MCM-41-SO₃H as a new efficient heterogeneous catalyst for the synthesis of celecoxib and pyrazole derivatives under room temperature is reported. The mesoporous material Ga-MCM-41 was first prepared and then functionalized with the sulfonic acid group by the post-synthetic modification to obtain the final solid acid catalyst. The successful grafting of the -SO₃H group onto the Ga-MCM-41 mesoporous walls was asserted by X-ray diffraction, scanning electron microscopy equipped with energy dispersive spectroscopy (SEM/EDS), and acid–base titration. The catalytic application of Ga-MCM-41-SO₃H in the synthesis of celecoxib and pyrazole derivatives has resulted in a high yield (up to 95%) under mild conditions. Notably, the Ga-MCM-41-SO₃H catalyst was stable and was able to reuse at least five times without losing significant catalytic activity.

Graphical abstract

Keywords: Celecoxib; Pyrazole; Ga-MCM-41-SO3H; Solid acid

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02452-1

Chemical Papers 77 (1) 89–99 (2023)