ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Structural elucidation of a Mn(III) derivative anchored with a tetradentate Schiff base precursor: in vitro cytotoxicity study

Kuheli Das, Manasa G. Shetty, Sindhoora K. Melanthota, Babitha K. Sundara, Sudeshna Kar, Chiara Massera, Eugenio Garribba, Amitabha Datta, and Nirmal Mazumder

Department of Chemistry, University of Calcutta, Kolkata, India

E-mail: amitd_ju@yahoo.co.in

Received: 9 September 2022  Accepted: 22 November 2022

Abstract:

A new mononuclear Mn(III) derivative, [Mn(L)(H₂O)₂]ClO₄ (1) was obtained by reacting manganese perchlorate with the tetradentate Schiff base precursor, H₂L, [where H₂L=C₆H₃(OMe)(OH)CH=N(CH₂)₃N=CH(OH)(OMe)C₆H₃] and characterized by various spectral techniques. Single crystal X-ray diffraction analysis revealed that in 1, the central Mn atom is hexa-coordinated via the NNOO donor sites of the Schiff base precursor and two water molecules, yielding a distorted octahedral geometry. Also, the EPR spectra of 1 were recorded at the solid state by varying the temperature (from 90 to 300 K) as well as in different organic solvents; DMSO, MeOH and a mixture CH₂Cl₂/toluene; the results obtained agree with the geometrical environment around the metal. The cytotoxic activity of the Mn(III) derivative was evaluated against normal and cancer cell lines. The derivative exhibited comparatively better cytotoxic activity against MCF-7 cells compared to SiHa and fibroblast cells.

Keywords: Manganese; Schiff base; X-ray structure; Spectra and biological activity

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02599-x

Chemical Papers 77 (4) 1989–1998 (2023)