ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera

Pradeep Kumar Pandey, Chinky Gangwar, Bushra Yaseen, Indresh Kumar, Rashmi Nayak, Saurabh Kumar, Radhey Mohan Naik, Monisha Banerjee, and Joy Sarkar

Department of Chemistry, Lucknow University, Lucknow, India

E-mail: dr.joysarkar4@gmail.com

Received: 26 August 2022  Accepted: 8 February 2023

Abstract:

Cancer is the second foremost cause of death worldwide, and despite modern medicine development, it is needed to develop new plant-based drugs. The current study is mainly focused on the estimation of anticancerous activity of silver nanoparticles (AgNPs) fabricated by a simple and eco-friendly green approach by using leaf extract of the medicinal plant Blumea lacera (B. lacera). The prepared AgNPs were characterized by using different analytical tools. UV–visible spectra were recorded, which exhibited a sharp surface plasmonic resonance (SPR) band at 430 nm and confirmed the formation of AgNPs. The spherical morphology of synthesized AgNPs was determined with the help of field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), and the average particle size was calculated using TEM and found to be 12.52 nm. The Fourier transformed infrared (FT-IR) spectrum of AgNPs showed characteristic bands of functional groups present in the biomolecules adsorb onto AgNPs, acting as a stabilizing agent. The crystallite nature of AgNPs formed was confirmed by the powder X-ray diffraction (PXRD) technique. The anticancerous activity of synthesized AgNPs was investigated against adherent human lung carcinoma cell A549. The minimal inhibition concentration (IC₅₀ or MIC) value was found to be ~ 20 μg/mL for human lung carcinoma cell A549, and the result so obtained suggests that synthesized AgNPs via B. lacera possess a good ability to be used as an eco-friendly anticancerous agent. Moreover, the synthesized AgNPs possess good antioxidant activity compared to B. lacera plant leaves. The minimal inhibition concentration (IC₅₀) of ~ 6 μg/mL for synthesized AgNPs was found.

Graphical abstract

Keywords: Silver nanoparticles; Green synthesis; Blumea lacera; Anticancerous activity; DPPH assay

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-02723-5

Chemical Papers 77 (7) 3603–3617 (2023)