ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Low-temperature aqueous growth of SDS-stabilized CuO electrocatalyst for ranitidine monitoring in pharmaceuticals

Jamil A. Buledi and Amber R. Solangi

National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan

E-mail: kjamil234@gmail.com

Received: 31 March 2023  Accepted: 23 June 2023

Abstract:

In this study, the synthesis of copper oxide (CuO) nanoparticles was carried out through aqueous chemical growth method by using sodium dodecyl sulphate (SDS) as stabilizing agent. Various analytical tools were exploited to examine the successful synthesis of SDS/CuO-NPs such as FTIR, XRD, SEM and EDX which revealed surface functionalities of SDS/CuO-NPs, phase purity and nanoflake-like morphology of the fabricated SDS/CuO-NPs. To examine the conductive nature of SDS/CuO-NPs, cyclic voltammetry mode was used. Various initial parameters were optimized such as phosphate supporting electrolyte pH (7), scan rate 80 mV/s for the sensitive and selective electrochemical determination of ranitidine drug. Moreover, through the optimized conditions, the developed SDS/CuO-NPs/Pt sensor showed exceptional Ipa response under the wide linear dynamic range from 0.01 to 30 µM with lower limit of detection (0.0016 µM). The analytical applicability of developed sensor was tested in the commercially available ranitidine drug samples with acceptable recovery results. The overall electrochemical determination process suggested that the developed sensor could be an effective aspirant for the determination of ranitidine drug in the pharmaceutical formulations at commercial level.

Keywords: Ranitidine drug; SDS/CuO-NPs; Cyclic voltammetry; Modified electrode; Pharmaceuticals

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-02946-6

Chemical Papers 77 (10) 6377–6386 (2023)