ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Breaking free from free radicals: harnessing the power of natural antioxidants for health and disease prevention

Priya Chaudhary, Pracheta Janmeda, William N. Setzer, Afaf Ahmed Aldahish, Javad Sharifi-Rad, and Daniela Calina

Department of Bioscience and Biotechnology, Banasthali Vidyapith, Newai, India

E-mail: priyachaudhary358@gmail.com

Received: 5 April 2023  Accepted: 5 November 2023

Abstract:

Massive production of the free radicals disrupts the system of antioxidant defense in the animal body thereby causing damage to cellular molecules (nucleic acid, lipids, protein, and cell membrane) which results to cell death or mutation that may give rise to abnormal cell division. Synthetic antioxidants such as butylated hydroxyanisole and butylated hydroxytoluene have been determined to be toxic to the health of human beings. Thus, the finding for nontoxic, effective, and safe natural compounds with potent antioxidant activities has been increasing in the last few years. Antioxidants are most frequently utilized in the control and management of oxidative stress-associated cancer and other diseases. The present review presents brief information on free radicals, their types, oxidative stress-directed effects and the function of natural and synthetic antioxidants in the control of cancer and other diseases.

Keywords: Oxidative stress; Antioxidants; Pathophysiology of diseases; Human health

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-03197-1

Chemical Papers 78 (4) 2061–2077 (2024)