ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

COF-LZU-1 [(TFB)₂(PDA)₃]_imine carrier for pH-controlled drug delivery

Gagandeep Kaur and Pawan Kumar

Material Application Research Lab. (MARL), Department of Nano Science and Materials, Central University of Jammu, Rahya Suchani, India

E-mail: pawannano10@gmail.com

Received: 19 December 2022  Accepted: 21 December 2023

Abstract:

A porous covalent organic framework, COF-LZU-1 [(TFB)₂(PDA)₃]_imine has been synthesized using 1,3,5-trisformylbenzene (TFB) and p-Phenylenediamine (p-PDA) in 1–4 Dioxane via Schiff base condensation reaction. The obtained crystalline material has been analyzed through X-ray diffraction, scanning electron microscopy, UV–Vis/photoluminescence spectroscopy, and Brunauer–Emmett–Teller (BET) surface area analyzer. After confirmation of the crystalline structure and hexagonal geometry of COF-LZU-1, the potential of COF for pH-controlled drug delivery has been demonstrated using spectroscopic techniques. The drug release profiles were estimated by varying pH values of 5.8, 6.8, and 7.4. The findings suggest maximum drug release % at pH-5.8 (90%) and minimum at pH-7.4 (24%), respectively. Overall, we have found out that the acidity of the medium has greatly influenced drug kinetics. Our primary spectroscopic results exhibit good estimation of drug loading and release profile in PBS buffer under variable pH.

Graphical abstract

Keywords: COF-LZU-1; Drug delivery applications; Ibuprofen; IBU@COF-LZU-1

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-03290-5

Chemical Papers 78 (5) 3023–3032 (2024)