ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, characterization, antimicrobial and antitubercular evaluation of nickel (II) complexes of ON donor quinoline-hydrazide core

Manasa Kongot, Riya Chaudhary, Dinesh S. Reddy, Anamika Sinha, Mahantesh M. Kurjogi, and Amit Kumar

Department of Chemistry, Manipal Institute of Technology Bengaluru, Manipal Academy of Higher Education, Manipal, Udupi, India

E-mail: dineshchem07@gmail.com

Received: 6 August 2023  Accepted: 5 January 2024

Abstract:

In the current work, non-toxic and safe Ni(II) complexes of unsymmetrical Schiff base ligand derived from Quinoline hybrid and isoniazid, viz. [Ni^II(Quibal-INH)₂] (1), [Ni^II(Quibal-INH)(cat)] (2) and [Ni^II(Quibal-INH)(bha)] (3), were synthesized. The complexes were characterized by elemental analysis and ATR-IR spectroscopy. These novel complexes were further preliminary evaluated for their solution stability in varied pH conditions. Furthermore, the interactions between Ni (II) complexes with human serum albumin (HSA) have been explored by using UV–visible spectroscopy. It was inferred that the complexes could quench the intrinsic fluorescence of HSA in a steady quenching process. The compounds were tested for their therapeutic potentials, viz. antibacterial, antifungal and anti-TB potential. In preliminary screening, nickel complexes (1) and (3) were active against Candida albicans with excellent growth inhibition. Nickel complex (1) was established as active and was assigned for further validation. For complexes 1 and 3, a toxicity test was performed on human embryonic kidney cells, and a hemolytic test was conducted on human red blood cells. Both complexes (1 and 3) were found to be non-toxic and safe. Nickel Complex (2) exhibited excellent anti-TB activity against the MTB H₃₇R_v strain, which was comparable to the standard TB drugs.

Graphical abstract

Keywords: Quinoline-hydrazide; ON donor Schiff base; Antimicrobial; Antitubercular; Antioxidant

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03307-7

Chemical Papers 78 (5) 3223–3232 (2024)