ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Poly(2-vinylpyridine) magnetite nanoparticles for 5-fluorouracil targeted delivery: synthesis, uptake and release study

I. V. Korolkov, K. A. Izbasar, Zh. A. Bekbol, A. V. Zibert, A. E. Shumskaya, L. I. Lissovskaya, L. N. Korganbayeva, and M. V. Zdorovets

The Institute of Nuclear Physics, Almaty, Kazakhstan

E-mail: i.korolkov@inp.kz

Received: 11 March 2024  Accepted: 2 September 2024

Abstract:

One of the major limitations of anti-cancer drugs is their poor selectivity and high toxicity. The present study aims to overcome these difficulties by developing targeted drug delivery systems. Drug delivery systems were synthesized based on magnetite nanoparticles with grafted poly(2-vinylpyridine) from their pre-modified surface with 3-(trimethoxysilyl)propyl methacrylate. The physical and chemical properties of synthesized samples were examined by Fourier-transform infrared spectroscopy, X-ray diffraction, vibrating-sample magnetometry, Energy-dispersive X-Ray analysis and thermogravimetric analysis. The size of nanoparticles was estimated by DLS, final Fe₃O₄-TMSPM-P2VP-5FU nanoparticles have an average size of 120 nm (PDI is 0.286). Release of 5-FU was examined at different pH (4.5 and 7.58) and constant temperature of 36.6 °C using UV–Vis spectroscopy.

Keywords: Iron oxide; Nanoparticle; Drug delivery; 5-FU

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03680-3

Chemical Papers 78 (16) 8599–8607 (2024)