ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, characterization, antimicrobial activity of 2-amino-5-picoline and dipicolinic acid of Ni(II) and Cu(II) metal complexes

Halil İlkimen, Sabiha Gözde Salün, Aysel Gülbandılar, and Musa Sarı

Department of Chemistry, Faculty of Arts and Sciences, Kütahya Dumlupınar University, Kütahya, Turkey

E-mail: halil.ilkimen@dpu.edu.tr

Received: 30 July 2024  Accepted: 9 October 2024

Abstract:

Ni(II) {(2a5p)₂[Ni(OH₂)₆][Ni(dipic)₂]₂.2H₂O, 1} and Cu(II) {[Cu(dipic)(2a5p)(H₂O)].H₂O, 2} complexes obtained from 2-amino-5-picoline (2a5p) with dipicolinic acid (H₂dipic) and Cu(II) complex {[(H₂O)(dipic)Cu(OH)Cu(OH)(H₂O)₂Cu(dipic)(H₂O)].2H₂O, 3} of H₂dipic have been synthesized and characterized by atomic absorption spectroscopy (AAS), ultraviolet–visible region (UV–Vis), Fourier transform infrared spectroscopy (FT-IR), conductivity measurement, magnetic measurement and X-ray crystallography. Furthermore, antimicrobial properties of starting and syntheses complexes have also been tested against C. krusei (ATCC 6258), C. albicans (ATCC 14053) and C. parapsilosis (ATCC 22019) (yeast) for antifungal activity and E. faecalis (ATCC 29212), E. coli (ATCC 25922) and S. aureus (ATCC 29213) for antibacterial activity. The antimicrobial activities of results were compared to those of standard agents such as fluconazole, levofloxacin, cefepime and vancomycin.

Keywords: Dipicolinic acid; 2-amino-5-picoline; Metal complex; Antifungal and antibacterial activity

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03736-4

Chemical Papers 78 (17) 9177–9189 (2024)