ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Some Transition Metal Complexes with Naproxen

M. Q. Zhang, Y. C. Zhu, J. G. Wu, P. Shi, R. W. Deng, and Z. N. Chen

School of Resources and Environment, Lanzhou University, Lanzhou, 730000, China

Abstract: Several transition metal complexes Of D-naproxen (HL) have been synthesized. Most of these complexes formed by the divalent metal ions have a 2:1 (ligand:metal) mole ratio and the carboxylate group of HL functions as a bridging ligand. Ni(H) and Cr(III) complexes exhibit a special composition and structure which possesses a free ligand coordinated to and bonded via hydrogen bonds, respectively. The inflammatory models by formaldehyde-induced rat paw edema and croton oil-induced mouse ear edema were used to examine the antiinflammatory action of the Cu(II) complex, which enhanced the antiinflammatory activity relative to the free ligand. The pharmaceutical synergy resulting from the coordination effect is discussed.

Full paper in Portable Document Format: 553a202.pdf

Chemical Papers 55 (3) 202–205 (2001)