ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, Characterization, and Antitumour Activity of Palladium(II) Complex of 5-Fluorouracil-l-acetic Acid and Ammine

J. Q. Qu, J. Huang, L. F. Wang, and G. C. Sun

National Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China

E-mail: qujq@netease.com

Abstract: Palladium(II) complexes of 5-fluorouracil-1-acetic acid (HL) and ammine have been prepared and characterized by means of elemental analysis, molar conductivity, IR, UV, ¹H NMR spectra, and TG-DTA. The general formula for the complex is PdL₂(NH₃)₂. The IR and ¹H NMR spectra show that HL and ammine coordinate to the metal ion through the ammine nitrogen and carboxyl oxygen. The complex and HL have been studied for their antitumour activity against HL-60 human leukemia cells in vitro.

Full paper in Portable Document Format: 555a319.pdf

Chemical Papers 55 (5) 319–322 (2001)