ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Characterization of Some New Mg(II) Complexes with Heterocyclic N-Donor Ligands and their Antimicrobial Effects

S. C. Mojumdar, D. Hudecová, M. Melník, and E. Jóna

Institute of Inorganic Chemistry, Slovak Academy of Sciences, SK-842 36 Bratislava

E-mail: uachmoju@savba.sk

Abstract: Synthesis, analytical data, IR spectra, as well as antimicrobial activities of 14 Mg(II) compounds are presented. Antimicrobial activities of 4 free ligands were also tested. By means of IR spectral analysis the stereochemistry around Mg(II) atom in the complexes had been studied. Methyl (3-pyridyl)carbamate (mpc), 3-(hydroxymethyl)pyridine (ron), and caffeine (caf) were coordinated to Mg(II) through the nitrogen atom of the respective heterocyclic ring. IR data suggest a unidentate coordination of carboxylate ions to Mg(II). The antimicrobial effects have been tested on various strains of filamentous fungi. A significant morphological change of Botrytis cinerea was observed with the compounds Mg(SCN)₂(mpc)₂ . 3H₂O and Mg(SCN)₂(caf)(2) . 7H₂O. The highest antimicrobial effects were manifested by the compound Mg(pc) H₂O (pc = pyridine-2,6-dicarboxylate), especially against filamentous fungi R. oryzae and dermatophytic fungi Microsporum gypseum (IC50 = 320 μg cm^-3 and 537 μg cm^-3, respectively). Antimicrobial effect of the compounds is decreased in the sequence: Microsporum gypseum, Botrytis cinerea, Rhizopus oryzae, Fusarium nivale, and Alternaria alternata.

Full paper in Portable Document Format: 541a39.pdf

Chemical Papers 54 (1) 39–44 (2000)