ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, Characterization, and Antitumour Activity of Isonicotinamido-4-bis(2-chloroethyl)aminobenzaldimine Complexes of Some Transition Metals

C. -Z. Li, S. -F. Zhou, X. -Z. Fan, Z. -F. Zhu, Y. -F. Ding, H. Zhao, C. -G. Xia, and L. -F. Wang

Laboratory of Applied Organic Chemistry, Lanzhou University, 730000 Lanzhou, China

Abstract: Isonicotinamido-4-bis(2-chloroethyl)aminobenzaldimine (IBAB) was synthesized through multistep reactions and characterized by spectral methods. The complexes M(IBAB)₂(NO₃)₂ (M = copper(II), nickel(II), cobalt(II), iron(III), zinc(II), and cadmium(II)) were isolated and characterized by elemental analysis, IR, UV VIS, and EPR spectra. The results show that IBAB binding to the metals is bidentate. In copper complex, IBAB is coordinated to the metal through carbonyl oxygen and azomethine nitrogen atoms. In the other complexes, which can form polymeric structure, IBAB is coordinated to the metal ions via amide nitrogen and pyridine nitrogen atom. The molar conductivity and spectral data suggest an octahedral geometry for the nickel(II), cobalt(II), and iron(III) complexes, a planar geometry for the copper(II) complex and a tetrahedral stereochemistry for the zinc(II) and cadmium(II) complexes. The data of antitumour activities indicate that the complexes have a definite cytotoxicity effect.

Full paper in Portable Document Format: 544a239.pdf

Chemical Papers 54 (4) 239–244 (2000)