ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Preparation and Properties of Magnesium(II) Compounds with Some Bioactive Ligands

S. C. Mojumdar, M. Melník, E. Jóna, and D. Hudecová

Institute of Inorganic Chemistry, Slovak Academy of Sciences, SK-842 36 Bratislava

E-mail: uachmoju@savba.sk

Abstract: Synthesis, analytical data, IR spectra, as well as antimicrobial activities of seventeen Mg(II) compounds are presented. By means of IR spectral analysis the stereochemistry around Mg(II) atom in the compounds had been studied. Pyridine, nicotinamide, and N,N-diethylnicotinamide were coordinated to Mg(II) through the nitrogen atom of their heterocyclic ring. IR data suggest a unidentate coordination of carboxylate ions to Mg(II). The antimicrobial effects have been tested on various strains of bacteria, yeasts, and filamentous fungi. The found antimicrobial effect of the compounds is decreased in the sequence: dermatophytes, phytopathogenic fungi, yeasts, and bacteria. Significant morphological changes of Botrytis cinerea were observed by the compounds VI and XVI. The highest antimicrobial effects were manifested by the compound V, especially against dermatophytic fungi Trichophyton terrestre and Microsporum gypseum (IC₅₀ = 623 μg cm^-3 and 642 μg cm^-3, respectively).

Full paper in Portable Document Format: 534a265.pdf

Chemical Papers 53 (4) 265–271 (1999)