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Collagen and Collagen/Hyaluronan Complex Modifications

D. Bakoš and D. Koniarová

Department of Plastics and Rubber, Faculty of Chemical Technology, Slovak University of Technology, SK-812 31 Bratislava

 

E-mail: bakos@cvt.stuba.sk

Abstract: Chemical analogues of extracellular matrix are mainly graft copolymers of collagen and glycosaminoglycans. The new complex matrix based on collagen and hyaluronan was used to develop a synthetic derma. The chemical treatment with hexamethylene diisocyanate with poly(oxyethylene glycol) resp. with poly(oxypropylene glycol) was chosen for improving mechanical properties. The study of mechanical properties, enzymatic degradation, and cytotoxicity after chemical treatment was first performed with pure collagen membranes and subsequently optimized to the complex membrane of collagen with hyaluronan. We suppose that the combination of excellent biological properties of both the polymers with lower enzymatic degradation and decreasing swelling after chemical modification can result in a valuable biomaterial for several medical applications.

Full paper in Portable Document Format: 536a431.pdf

 

Chemical Papers 53 (6) 431–435 (1999)

Wednesday, September 28, 2022

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