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Matrix Effects in Membrane Introduction Mass Spectrometry. 1. Effect of Polyethylene Glycol) on Permeation Rate of 1-Octanol through Silicone Rubber Membrane

I. Jelínek

Department of Analytical Chemistry, Faculty of Natural Sciences, Charles University, CZ-128 40 Prague


Abstract: Simple flow-through capillary membrane interface, suitable for direct measurement of organic compounds in aqueous samples, has been built and its function verified on aqueous solution of 1-octanol. Optimization of experimental conditions involving the adjustment of ion source and inlet transfer line temperatures and the modification of sample solution flow rate resulted in short response time (lower than 1 min), high stability of measured signal and high sensitivity toward 1-octanol. Possible matrix effects of poly(ethylene glycol) (PEG) on the permeation rate of 1-octanol were studied. Both adsorption of PEG on the inner membrane surface and formation of PEG-octanol complexes were recognized as important factors decreasing the measured signal. An attempt to estimate the PEG-octanol binding ratio from available experimental data was made.

Full paper in Portable Document Format: 503a131.pdf


Chemical Papers 50 (3) 131–137 (1996)

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