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Study of the Mixed Ligand Complexes of Cadmium(ll) with the Antidepressant Drug Imipramine and Glutamic Acid or Histidine Using Polarography

M. Khodari, M. A. Ghandour, H. Mansour, and H. S. Eldin

Department of Chemistry, Faculty of Science, Assiut University, Qena, Egypt


Abstract: The stability constants of binary and ternary complexes of Cd(ll) with glutamic acid (Glu) or histidine (His) as a primary ligand and imipramine (lmip) as a secondary one have been determined polarographically. The reduction process of both simple and mixed systems is reversible and diffusion-controlled. For the system Cd-Glu-lmip, two mixed complexes were formed: Cd(Glu)(lmip)2 and Cd(Glu)2(lmip) with stabilities log {β12} = 11.45 and log {β21} = 10.26, respectively. But the system Cd-His-lmip forms three mixed complexes, Cd(His)(lmip), Cd(His)(lmip)2, and Cd(His)2(lmip). The calculated stability constants of these complexes are log {β11} = 7.17, log {β12} = 10.39, and log{β21} = 9.7, respectively.

Full paper in Portable Document Format: 491a21.pdf


Chemical Papers 49 (1) 21–23 (1995)

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