ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis of Some New Piperazine-N´N'-bis-substituted Derivatives As Potential Biologically Active Agents

S. G. Abdel-Hamide, H. M. El-Shaaer, H. A. Allimony, S. A. Abdel-Aziz, and R. A. Abdel-Rahman

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alazhar University, Cairo, Egypt

Abstract: In a search for new bactericidal and fungicidal agents some new piperazine-N,N'-bis-substituted derivatives have been prepared and characterized by their elemental analysis, IR, ¹H NMR, and mass spectral data. The antibacterial and antifungal activities of all prepared compounds have been determined using Gentamycin as standard antibiotic. Some compounds showed a high activity equivalent to that of the standard towards Escherichia coli, Serratia marcescens, Bacillus cereus, Staphylococcus aureus, and Candida albicans.

Full paper in Portable Document Format: 493a142.pdf

Chemical Papers 49 (3) 142–148 (1995)