ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis of 2-Acylaminobenzimidazoles from Acyl Isothiocyanates and o-Phenylenediamine

P. Kutschy, V. Ficeri, and M. Dzurilla

Department of Organic Chemistry, Faculty of Natural Sciences, P. J. Šafárik University, SK-041 67 Košice

Abstract: Acyl isothiocyanates react with o-phenylenediamine in anhydrous acetonitrile in the presence of dicyclohexylcarbodiimide as cyclodesulfurizing agent with the formation of acyl derivatives of 2-aminobenzimidazole. Intermediates of the reaction are corresponding N-(2-aminophenyl)-N'-acylthioureas readily formed at laboratory temperature, which cyclize to benzimidazole derivatives by the action of dicyclohexylcarbodiimide in boiling acetonitrile.

Full paper in Portable Document Format: 481a39.pdf

Chemical Papers 48 (1) 39–42 (1994)