ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

¹³C NMR Study of 1-Substituted 2-Тhioхо-4(1H,ЗН)-quinazolinones Employing the 1D and 2D Methods

J. Imrich, T. Bušová, D. Koščik, and T. Liptaj

Department of Organic Chemistry, Faculty of Natural Sciences, P. J. Šafárik University, CS-041 67 Košice

Abstract: The ¹³C  and ¹H  NMR spectra of the title compounds and their 2-oxo analogue were studied by one- and two-dimensional methods COSY and INEPT. The chemical shifts were unambiguously ascribed to compounds under investigation and the coupling constants J(H, C) of the 4-quinazolinone ring system were determined by the 2D-J selective INEPT. Relationship between localization of the multiple bond in the diazine ring and the ¹³C  chemical shift values is discussed. The obtained values allowed us to deduce the SCS increments of 2-thioxo-4(lH,3H)-quinazolinon-1-yl grouping on the aromatic ring.

Full paper in Portable Document Format: 472a102.pdf

Chemical Papers 47 (2) 102–105 (1993)