ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Investigation of 8-mercaptoquinoline (thiooxine) and its derivatives. 120. Synthesis and physicochemical properties of 6-methylthio-8-mercaptoquinoline

J. Lejejs, Y. Bankovskii, A. Bruvere, P. Brusilovskii, and M. Zikmund

Institute of inorganic Chemistry, Latvian Academy of Sciences, 229021 Salaspils

Abstract: A new derivative of 8-mercaptoquinoline, 6-methylthio-8-mercaptoquinoline (VIII), has been synthesized and its electronic absorption spectra, ionization constants, as well as the extraction by organic solvents were investigated. The maxima in the electronic absorption spectra of VIII in comparison with 8-mercaptoquinoline (and especially with 6-methoxy-8-mercaptoquinoline) are shifted bathochromically. The main properties of the nitrogen atom in VIII are less pronounced than in 8-mercaptoquinoline, and also in 4-, 5-, and 7-methylthio derivatives. As regards the value of the constants of distribution between the organic solvents and water, VIII falls behind 2- and 5-, but surpasses 4- and 7-methylthio derivatives.

Full paper in Portable Document Format: 455a657.pdf

Chemical Papers 45 (5) 657–666 (1991)