ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, Characterization, Antitumour and Antibacterial Activity of Rare Earth Metal(III) Solid Complexes with Tetraiodofluorescein

J. Q. Qu, L. F. Wang, X. P. Zhang, H. Zhao, and And G. C. Sun

National Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China

E-mail: qujq@netease.com

Received: 28 December 2000

Abstract: Eight new solid complexes of tetraiodofluorescein (H2L) with rare earth metals have been prepared and characterized by means of elemental analysis, molar conductivity, IR, ¹H NMR, XPS, and TGDTA. The general formula for the complexes is M₂L₃ · nH₂O, where L = tetraiodofluorescein (2,7- OH group deprotonated and the lactonic ring opened); M = La, Ce, Pr, Nd, Sm, Eu, Gd or Y; n = 8, 9, 10, 11 or 14. In vitro, H₂L and its complexes have been studied for their possible antitumour activity against Hep-2 pharynx cancer cells and their possible antibacterial activity against Shigella flexner F2a, Salmonella typhi H034, and Staphylococcus aureus.

Full paper in Portable Document Format: 562a113.pdf

Chemical Papers 56 (2) 113–116 (2002)