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Kinetics of hydrolysis of 2-substituted 4,5-dichloro-3-oxo-2H-pyridazines

V. Konečný, J. Muchová, A . Jurášek, and P. Zahradníik

Research Institute of Chemical Technology, CS-83J 06 Bratislava

Abstract: The kinetics of hydrolysis of 2-R-4,5-dichloro-3-oxo-2H-pyridazines (R = CH₃, C₃H₇, (CH₃)₂CH, C₄H₉, (CH₃)₃C, C₅H₁₁ , C₆H₁₁ (cyclo), C₆H₅ , CH₂—C₆H₅ , CH₂ —C₆H₄ -CH₃) has been studied. The products of the reaction were found to be the respective 2-R-4-chloro-5-hydroxy-3-oxo-2H-pyridazines, i.e. only the chlorine bound in position 5 entered the reaction. The probable mechanism and the effect of the substituent on hydrolysis have been explained.

Full paper in Portable Document Format: 434a547.pdf

Chemical Papers 43 (4) 547–551 (1989)