ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

The rate of acid-catalyzed solvolysis and tuberculostatic activity of thioamides

J. Mollin, H. Paukertová, and Ž. Odlerová

Department of Inorganic and Physical Chemistry, Faculty of Natural Sciences, Palacký University, CS-771 46 Olomouc

Abstract: The dependence of rate  constant of acid-catalyzed solvolytic reaction of thioamides on concentration of the acid as well as the entropy of activation and pos. value of the ϱ constant in the Hammett equation has confirmed in accordance with literature the suggested S_N2 mechanism of this reaction for the whole investigated groups of substances. The uniformity of reaction mechanism made possible a correlation of the determined rate constants with microbial activity  of these substances.

Full paper in Portable Document Format: 385a629.pdf

Chemical Papers 38 (5) 629–636 (1984)