ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Chromatographic parameters of dimethylammonioethyl alkoxycarbanilate chlorides

M. Bachratá, J. Čižmárik, Ž. Bezáková, M. Blešová, and A. Borovanský

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Komenský University, CS-832 32 Bratislava

Abstract:  Conditions were found to separate dimethylammonioethyl alkoxycarbani­ late chlorides by thin-layer chromatography on silica gel and cellulose. The R_M values were calculated from the R_f and ΔR_M values for the methylene increment in homologic series of compounds. A linear relationship between the RM values from partition chromatography and the partition coefficient mea­ sured (log P') or the substitution constant π was ascertained. The R_M values were also employed for correlation with the anaesthetic activity (log U).

Full paper in Portable Document Format: 372a217.pdf

Chemical Papers 37 (2) 217–224 (1983)