ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Cryoscopic properties of aqueous solutions of heptacaine and some of its analogs

F. Kopecký, V. Záhorka, M. Vojteková, and J. Čižmárik

Department of Physical Chemistry, Faculty of Pharmacy, Komenský University, 880 34 Bratislava

Abstract: Freezing point depressions of the diluted aqueous solutions of a new local anaesthetic heptacaine (7V-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]piperidinium chloride) and four its analogues were measured, as well as some of their mixed solutions with urea. The derived osmotic data pointed out various degrees of self-association of the studied substances and their interaction with urea in aqueous solutions.

Full paper in Portable Document Format: 321a42.pdf

Chemical Papers 32 (1) 42–50 (1978)