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Benzothiazole compounds. XI. Synthesis and antimicrobial activity of 2- and 2,6-substituted benzothiazoles

V. Sutoris, P. Foltínová, and G. Blőckinger

Department of Organic Chemistry, Faculty of Natural Sciences, Komenský University, 816 31 Bratislava

 

Abstract:  2-Substituted and 2,6-disubstituted thiobenzothiazoles were synthesized. They were found to show good antimicrobial activities on non-specific bacterial flora, mycobacteria, protozoa, and pathogenic fungi. The highest activity was found with 2-allylthiobenzothiazole (XIV), 2-allylthio-6-nitrobenzothiazole (XV), 2-allylthio-6-aminobenzothiazole (XVI), 2-propargylthiobenzothiazole (XVIII), 2-propargylthio-6-nitrobenzothiazole (XIX), and 2-propargylthio-6-aminobenzothiazole (XX).

Full paper in Portable Document Format: 311a92.pdf

 

Chemical Papers 31 (1) 92–97 (1977)

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