ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Effect of tertiary amines and their related compounds on the oxidation of unsaturated fatty acids

I. Lacko, J. Kaláč, and R. K Joshi

Research Institute, Faculty of Pharmacy, Komenský University, 880 34 Bratislava

Abstract:  The relationship between substituent effects on an aromatic nucleus of aryloxyalkylpiperidine, the length of the linking aliphatic chain and substituents on nitrogen on the one hand and the antioxidant and inhibitory activity on the other has been investigated. From the course of autoxidation, oxidation of unsaturated fatty acids (linoleic, linolenic, arachidonic) catalyzed by lipoxygenase and from the examination of degradation of ß-carotene it has been found that the greatest stabilizing and inhibitory effects have 1-[4-(4-íerí-butylphenoxy)butyl]piperidine, 1-[4-(2-tert-butylphenoxy)butyl]-piperidine, and l1[4-(4-hexyloxyphenoxy)butyl]piperidine.

Full paper in Portable Document Format: 281a120.pdf

Chemical Papers 28 (1) 120–127 (1974)