ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Alkalimetric determination of hydrophobic pharmaceuticals using stabilized o/w emulsions

Ganna M. Shevchenko and Sergey A. Kulichenko

Analytical Chemistry Department, Faculty of Chemistry, Taras Shevchenko Kyiv University, Volodymyrska Str. 64, Kyiv, 01033, Ukraine

E-mail: shevanna@ukr.net

Received: 21 September 2007  Revised: 27 November 2007  Accepted: 3 December 2007

Abstract: Protolytic properties of (+)-(S)-2-(6-methoxynaphthalen-2-yl)propanoic acid (naproxen), 2-(3-benzoylphenyl)propionic acid (ketoprofen), 4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid (furosemide), and N-(2,3-dimethylphenyl)anthranilic acid (mefenamic acid) in “oil-in-water” emulsions stabilized by surfactants were studied. The procedures for alkalimetric determination of naproxen, ketoprofen, furosemide, and mefenamic acid in emulsion media with indication of the equivalence point pH-metrically and with the use of indicators were proposed.

Keywords: pK - protolytic properties - hydrophobic pharmaceuticals - emulsion media - alkalimetric determination

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-008-0038-7

Chemical Papers 62 (4) 435–439 (2008)