ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Determination of Small Amounts of Thiacetazone in Serum

D. Stangelová, L. Molnár, and A. Lukáčová

Institute of Experimental Pharmacology 9 Slovak Academy of Sciences, Bratislava 9

Abstract: A modification of the method described in the literature for Thiacetazone determination in blood serum by means of UV spectrophotometry is presented together with an evaluation of its results. Quantitative data are obtained from absorbance values read off at 330 nm, but an absorption curve in the 310 —340 nm range of wavelength is prepared for each sample separately. A correct evaluation of the absorption curve enables results to be obtained even with a Thiacetazone serum concentration below 0.5 ( μg/ml and in addition, it permits artefacts caused by the absorbance of interfering agents, to be detected. The method is quick, without great technical exigencies and at the same time sensitive and reproducible.

Full paper in Portable Document Format: 2311-12a928.pdf

Chemical Papers 23 (11-12) 928–933 (1969)