ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Mass Spectrometric Study of Platinum Complexes Based on Cisplatin

P. Doležel and V. Kubáň

Department of Chemistry and Biochemistry, Mendel University of Agriculture and Forestry, CZ-613 00 Brno

E-mail: kuban@mendelu.cz

Received: 22 October 2001

Abstract: Flow injection-electrospray ionization-mass spectrometric and liquid chromatography-UV spectrometry- electrospray ionization-mass spectrometric systems with the possibility of collision-induced dissociation were used for characterization of Pt(II) and Pt(IV) complexes well known as antitumour agents. Mass spectra of cis-platin and trans-platin [Pt^II(NH₃)₂Cl₂]⁰ under various experimental conditions were compared. Ion clusters and adduct ions with the assumed structure are described. The process of partial ion fragmentation allows characterization of the LA12 product, [Pt^IV(C₁₀H₁₇N)(NH₃)(CH₃COO)₂Cl₂]⁰, a new agent with enhanced cancerostatic activity. The structure of the principal impurity, [Pt^IV(C₁₀H₁₇N)(NH₃)(CH₃COO)₂Cl₂]⁰, present in the final product of the LA12 synthesis, was designed after chromatographic separation and subsequent mass spectra analysis.

Full paper in Portable Document Format: 564a236.pdf

Chemical Papers 56 (4) 236–240 (2002)