ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7

Published monthly
 

Synthesis, Physicochemical Properties, and Conformational Studies of (3-Alkoxymethyl-4-hydroxyphenyl)ethanones

R. Čižmáriková, M. Polakovičová, and E. Mišíková

Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, SK-832 32 Bratislava

 

E-mail: Cizmarikova@fpharm.uniba.sk

Received: 26 October 2001

Abstract: A homologous series of (3-alkoxymethyl-4-hydroxyphenyl)ethanones was prepared by the reaction of (3-chloromethyl-4-hydroxyphenyl)ethanone with the different alcohols in the presence of sodium hydrogen carbonate. The confirmation of structures was achieved by interpretation of IR, UV, and 1H NMR spectra. Molecular modeling methods were used to establish conformations with global and local energetic minima. It was found that energetically the most stable conformations involved hydrogen bond formation between the hydrogen of phenolic group and the oxygen of alkoxyl group. Enthalpy values of hydrogen bonds of selected compounds were 24.86—30.51 kJ mol−1 and their distances were in the range 0.282—0.293 nm.

Full paper in Portable Document Format: 564a256.pdf

 

Chemical Papers 56 (4) 256–260 (2002)

Friday, July 19, 2024

IMPACT FACTOR 2023
2.1
SCImago Journal Rank 2023
0.381
SEARCH
Advanced
VOLUMES
© 2024 Chemical Papers