ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Electrospray ionization mass spectra of pentoses, hexoses, and 2-deoxy-2-fluoro-d -glucose

Peter Brúder, Fedor Macášek, and Emília Búriová

Department of Nuclear Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-1, SK-84215 Bratislava, Slovakia

E-mail: bruderp@hotmail.com

Received: 14 January 2008  Revised: 10 April 2008  Accepted: 17 April 2008

Abstract: Electrospray ionization (ESI) mass spectra of hexoses, pentoses, and 2-deoxy-2-fluoro-d-glucose (FDG) were investigated and compared using liquid chromatography/mass spectroscopy (LC/MS). ¹⁸F-FDG is one of the most widely used radiopharmaceuticals. This work is aimed at the possible interpretations of ESI mass spectra and at the comparison of various pentoses (arabinose, ribose, xylose), and hexoses (glucose, fructose, galactose, mannose) which can be formed during the ¹⁸F-FDG’s synthesis or decomposition. As a result, nine major associates were found in the positive and four in the negative mass spectra of all examined saccharides of which intensities and mass can be used with their retention times to determine the saccharide. M · NH₄⁺ and M · COOH⁻ were identified as the most stable associates.

Keywords: monosaccharides - mass spectroscopy - liquid chromatography - 2-deoxy-2-fluoro-d-glucose

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-008-0073-4

Chemical Papers 62 (6) 547–552 (2008)