ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Polymer interfaces used in electrochemical DNA-based biosensors

Júlia Galandová and Ján Labuda

Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, 812 37 Bratislava, Slovakia

E-mail: jan.labuda@stuba.sk

Received: 26 March 2008  Revised: 30 July 2008  Accepted: 4 September 2008

Abstract: Nowadays DNA-based biosensors represent powerful tools for the study of DNA sequence, DNA chemical interactions and damage. Among them, biosensors with an electrochemical signal transducer play the most important role. The performance of a biosensor strongly depends on the method of a biorecognition element being attached to the electrode. This review refers to polymer materials being used to create a DNA-electrode interface. The main terminology is given in Introduction followed by a description of polymers and polymer-based nanocomposites and their electrochemical properties. A comprehensive table reports examples of the electrochemical detection of DNA immobilized on the polymer matrix. Finally, a short survey is given.

Keywords: DNA biosensor - electrode - polymer - nanocomposite - surface modification

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-008-0083-2

Chemical Papers 63 (1) 1–14 (2009)