ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Adsorption and release of terbinafine hydrochloride: Effects of adsorbents, additives, pH, and temperature

Zuzana Vitková, Jarmila Oremusová, and Oľga Greksáková

Department of Galenic, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic

E-mail: vitkova@fpharm.uniba.sk

Received: 18 March 2008  Revised: 9 September 2008  Accepted: 22 September 2008

Abstract: The paper describes results obtained within the study of factors affecting the process of an antifungal drug — terbinafine hydrochloride adsorption on two different adsorbents — charcoal and silicagel. The effects of the adsorbent area, pH value, temperature and additives (polymers — methyl cellulose and hydroxypropyl cellulose) were analyzed and their impact on the adsorption of terbinafine was derived. The increase of pH and temperature, and the presence of additives decreased the amount of terbinafine adsorbed on the adsorbents. Terbinafine is currently applied both perorally and topically. Hydrogels, i.e. compositions of a drug, additives and water, are, due to their advantageous properties, preferred topical dosage forms. Mass fraction of additives of 1 % to 4 % were studied from the view point of drug release. This study shows that both the sort and the concentration of polymers influence the drug release from hydrogels significantly.

Keywords: terbinafine - adsorption - pH influence - adsorption isotherms - hydrogel - drug release

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-009-0023-9

Chemical Papers 63 (3) 345–350 (2009)