ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, spectral description, and lipophilicity parameters determination of phenylcarbamic acid derivatives with integrated N-phenylpiperazine moiety in the structure

I. Malík, E. Sedlárová, J. Csöllei, F. Andriamainty, P. Kurfürst, and J. Vančo

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, SK-832 32 Bratislava, Slovakia

E-mail: malik@fpharm.uniba.sk

Received: 9 February 2005  Revised: 13 June 2005  Accepted: 20 June 2005

Abstract: The phenylcarbamic acid derivatives with N-phenylpiperazine moiety in the molecule have been prepared. The structure has been confirmed by elemental analysis, IR, ¹H NMR, and mass spectral data. For the prepared set of the compounds the lipophilicity parameters have been determined. The experimentally obtained lipophilicity parameters have been correlated with theoretical entries obtained by different computer programs based on the neural network and fragmental methods.

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-006-0007-y

Chemical Papers 60 (1) 42–47 (2006)