ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, characterization, and anti-tumor activities of some transition metal(II) complexes with podophyllic acid hydrazide

Jian-Qiang Qu, Ling Qu, Qiu-Hua Yang, and Liu-Fang Wang

Department of Chemistry, School of Science, Tianjin University, Tianjin, 300072, China

E-mail: jqqu@tju.edu.cn

Received: 7 July 2008  Revised: 11 November 2008  Accepted: 18 November 2008

Abstract: Four transition metal(II) complexes with podophyllic acid hydrazide (HL) were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR, and ¹H NMR. The complexes have the general formula ML₂ · nH₂O, where M = Zn, Cu, Co, and Ni, n = 2 or 0. Anti-tumor activities of podophyllotoxin, HL, ZnL₂ · ₂H₂O, and NiL₂ were tested by both the MTT and the SRB method. The results show that the activities of the complexes against the tumor cells tested are superior to HL and the anti-tumor activity of NiL2 is even similar to that of podophyllotoxin.

Keywords: transition metal - complexes - podophyllic acid hydrazide - anti-tumor activities

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-009-0033-7

Chemical Papers 63 (4) 426–431 (2009)