ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes

Ajay K. Mishra, Shivani B. Mishra, and Narender K. Kaushik

Department of Chemical Technology, University of Johannesburg, Doornfontein, 2028, South Africa

E-mail: ajaykmishra1@yahoo.com

Received: 9 October 2008  Revised: 1 December 2008  Accepted: 4 December 2008

Abstract: Synthesis, characterization and biological studies of some thiodiamine metal complexes are described. Cobalt(II) and copper(II) complexes of type [Cu(L)₂Cl₂] and [Co(L)₂SO₄], where L = (cyclohexyl-N-thio)-1,2-ethylenediamine (L¹) and (cyclohexyl-N-thio)-1,3-propanediamine (L²), were synthesized. The synthesized copper and cobalt thiodiamine complexes were characterized by elemental analysis, IR, mass, UV-VIS and ¹H NMR spectroscopic studies. Thiodiamines coordinate as a bidentate N-S ligand. The binding sites are azomethine nitrogen and thioamide sulfur. Molar conductance values in dimethylsulfoxide indicate non-electrolyte nature of the complexes. In vitro-antimicrobial screening shows promising results against both bacterial and fungal strains.

Keywords: synthesis - thiodiamine - spectral - antibacterial - antifungal

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-009-0049-z

Chemical Papers 63 (5) 543–547 (2009)