ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

A new titration determination of N-alkylamino derivatives of phenothiazine

G. Dušinský and O. Lišková

Staatliches Institut für Heilmittelkontrolle, Gebietsinstitut für die Slowakei in Bratislava

Abstract: The suitable conditions for oxidimetric titration of N-alkylamino derivs. of phenothiazine (I), i.e. chloropromazine, diparcol, and phenergan, were studied. Under the favorable acidic conditions in titrations with Ce(SO₄)₂ and KBrO₃ (in the presence of KBr) a red-colored semiquinoidinic free radical of I is formed when the electron is removed; this radical becomes colorless when an addnl. electron is removed. The titration is possible in the presence of other org. N-contg. heterocyclic compds. The reaction of chloropromazine with Ce(SO₄)₂ solns. is stoichiometric and occurs instantly.

Full paper in Portable Document Format: 124a213.pdf (in Slovak)

Chemical Papers 12 (4) 213–220 (1958)