ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Mesoporous nanocrystalline MgAl₂O₄: A new heterogeneous catalyst for the synthesis of 2,4,6-triarylpyridines under solvent-free conditions

Javad Safari, Zohre Zarnegar, and Mahmoud Borjian Borujeni

Laboratory of Organic Chemistry Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, P.O Box 87317-51167, Kashan, Iran

E-mail: Safari@kashanu.ac.ir

Abstract: In this paper, one-pot synthesis of 2,4,6-triarylpyridine by condensation of subsisted acetophenone (II), aromatic aldehydes (I), and ammonium acetate (III) in the presence of nanocrystalline MgAl₂O₄ as a new heterogeneous catalyst under solvent-free conditions is reported. Advantages of this method are the use of spatially-hindered aldehydes such as 2-methoxy-, 2-fluoro-, and 2-chlorobenzaldehydes, a new nanocatalyst with high surface area, shorter reaction time, easier workup, higher yield, and its environmental friendliness. The performance of this reaction under solvent free conditions using heterogeneous catalysts like MgAl₂O₄ could enhance its efficiency from an economic as well as green chemistry point of view.

Keywords: one-pot synthesis – multicomponent reactions – heterogeneous catalyst – nanocrystalline magnesium aluminate – solvent-free

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-013-0361-5

Chemical Papers 67 (7) 688–695 (2013)