ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Potassium phthalimide-catalysed one-pot multi-component reaction for efficient synthesis of amino-benzochromenes in aqueous media

Hamzeh Kiyani and Fatemeh Ghorbani

School of Chemistry, Damghan University, Damghan, 36715-364, Iran

E-mail: hkiyani@du.ac.ir

Abstract: 2-Amino-4-aryl-4H-benzo[h]chromenes and 3-amino-1-aryl-1H-benzo[f]chromenes were prepared by treating cyano-methylene compounds (malononitrile or ethyl cyanoacetate), substituted aromatic aldehydes, and naphtholic compounds in the presence of potassium phthalimide as a green, mild, efficient, and commercially available organocatalyst in aqueous media. The procedure was readily conducted and affords remarkable advantages such as safety, short reaction times, environmentally benign milder reaction conditions, no organic solvent required, and high yields.

Keywords: three-component process – amino-benzochromene – potassium phthalimide – nitrile compounds

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-014-0554-6

Chemical Papers 68 (8) 1104–1112 (2014)