ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation

Da-Wei Zhang, Yu-Min Zhang, Yi-Liang Zhang, Tian-Qi Zhao, Hong-Wei Liu, Yuan-Ming Gan, and Qiang Gu

College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, China

E-mail: guq@jlu.edu.cn

Abstract: An efficient synthesis of bis(indolyl)methanes was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98 %). Solid support SiO₂ was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring were synthesized via this method in excellent yields (> 94 %) using 3-substituted isoxazole-5-carbaldehydes and indole.

Keywords: bis(indolyl)methanes – microwave synthesis – bis(indolyl)methanes containing isoxazolering – SiO2 solid support – solvent-free

Full paper is available at www.springerlink.com.

DOI: 10.1515/chempap-2015-0036

Chemical Papers 69 (3) 470–478 (2015)