ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

ZnO nanoparticles in the synthesis of AB ring core of camptothecin

Selvaraj Mohana Roopan and Fazlur Rahman Nawaz Khan

Organic & Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, India

E-mail: nawaz_f@yahoo.co.in

Abstract: For the first time, synthesis of AB ring core of camptothecin synthons such as (2-chloroquinolin-3-yl)methanols (Va-Vg) using zinc oxide nanoparticles is reported. The desired attractive products were obtained in high yields, short reaction time, using a simple work-up procedure with the purification of products by non-chromatographic methods.

Keywords: ZnO nanoparticles - camptothecin synthons - (2-chloroquinolin-3-yl)methanol

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-010-0058-y

Chemical Papers 64 (6) 812–817 (2010)